Diindolylmethane (DIM) Information Resource Center

Diindolylmethane (DIM)
Information Resource Center

An Initiative of Faculty Members and Research Fellows at the
University of California at Berkeley

An Initiative of Faculty Members and
Research Fellows at the
University of California at Berkeley

Diindolylmethane (DIM) Information Resource Center

Diindolylmethane (DIM) Information Resource Center References Section

Providing References for Biomedical Investigators Conducting Research on Diindolylmethane (DIM) and DIM Supplement Formulations

Diindolylmethane (DIM) Scientific Reference 1 from 1975:

J Natl Cancer Inst. 1975 Apr;54(4):985-8. Aryl hydrocarbon hydroxylase induction in rat tissues by naturally occurring indoles of cruciferous plants. Loub WD, Wattenberg LW, Davis DW.

A phytochemical investigation to identify inducers of increased aryl hydrocarbon hydroxylase (AHH) activity from three cruciferous vegetables, Brussels sprouts, cabbage, and cauliflower, resulted in the identification of indole-3-acetonitrile, indole-3-carbinol, and 3,3′-diindolylmethane (DIM) as naturally occurring inducers. These compounds are produced during the hydrolysis of indolyl-methyl glucosinolate by the plant enzyme myrosinase.