Diindolylmethane (DIM) Scientific Reference J Natl Cancer Inst. 1975 Apr;54(4):985-8.
Aryl hydrocarbon hydroxylase induction in rat tissues by naturally occurring
indoles of cruciferous plants.
Loub WD, Wattenberg LW, Davis DW.
A phytochemical investigation to identify inducers of increased aryl hydrocarbon
hydroxylase (AHH) activity from three cruciferous vegetables, Brussels sprouts,
cabbage, and cauliflower, resulted in the identification of
indole-3-acetonitrile, indole-3-carbinol, and 3,3′-diindolylmethane as naturally
occurring inducers. These compounds are produced during the hydrolysis of
indolyl-methyl glucosinolate by the plant enzyme myrosinase.
PMID: 1127728